SR 33805 oxalate

>96%

L-type Ca2+ channels

Synthetic

SR 33805 oxalate (#S-105) is a highly pure, synthetic, and biologically active compound.

654.77

SR 33805, a fantofarone derivative, is a potent Ca2+ channel antagonist1. It binds allosterically to the α1-subunit of L-type Ca2+ channels (Kd = 20 pM), at a site distinct from other types of blockers2. It potently inhibits the Ca2+ channel in primary mouse cardiac myocytes cultures with IC50 values ranging from 4 to 33 nM3.

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

1 nM - 10 μM.

Lyophilized

C32H40N2O5S.C2H2O4.

121346-32-5

Up to four weeks at 4°C or three months at -20°C.