Penicolinate B

A fungal metabolite with diverse biological activities

Penicolinate B is a fungal metabolite originally isolated from Penicillium that has diverse biological activities.1 It is active against M. tuberculosis (MIC = 25 µg/ml), as well as P. falciparum, B. cereus, and C. albicans (IC50s = 1.4, 25, and 3.67 µg/ml, respectively). Penicolinate B is cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 6.21, 17.78, 0.307, and 2.79 µg/ml, respectively).

398.5

≥95%

Penicolinate A monomethyl ester

O=C(C1=NC=C(CCCCCCCCCCC2=CN=C(C(OC)=O)C=C2)C=C1)O

C23H30N2O4

1418291-70-9

≥ 4 years

DMSO: soluble Methanol: soluble