m-Chlorophenylbiguanide hydrochloride

m-Chlorophenylbiguanide hydrochloride is a potent and selective SR-3/HTR3 agonist. 参考文献 Kilpatrick et al (1990) 1-(m-Chlorophenyl)biguanide, a potent high affinity 5-HT3 receptor agonist. Eur.J.Pharmacol. 182 193. Sepulveda et al (1991) The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT3 receptors in N1E-115 neuroblastoma cells. Br.J.Pharmacol. 104 536. Boess et al (1992) 5HT3 receptors in NG108-15 neuroblastoma X glioma cells: effect of the novel agonist 1-(m-chlorophenyl)biguanide. Neuropharmacology 31 561. Niemeyer and Lummis (1998) Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment. Br.J.Pharmacol. 123 661.

248.11

m-Chlorophenylbiguanide hydrochloride is a prototypical potent and selective SR-3 agonist

M-CPBG hydrochloride

C1=CC(=CC(=C1)Cl)N=C(N)N=C(N)N.Cl

C8H10CIN5•HCl

2113-05-5