AZD 9272

A negative allosteric modulator of mGluR5 receptors

AZD 9272 is a brain-penetrant negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5; IC50 = 7.6 nM in a FLIPR calcium mobilization assay).1 It is selective for mGluR5 over mGluR1-4 and 6-8 in a FLIPR calcium mobilization assay (IC50s = >30 µM) and a panel of 134 receptors, ion channels, nuclear hormone receptors, transporters, and enzymes at 10 µM in radioligand binding assays.

284.2

≥98%

FC1=CC(C#N)=CC(C2=NC(C3=NC=C(F)C=C3)=NO2)=C1

C14H6F2N4O

327056-26-8

≥ 4 years

DMSO: 50 mM