BCTC

>99% (HPLC)

TRPV1 and TRPM8 channels

Synthetic

BCTC (#B-110) is a highly pure, synthetic, and biologically active compound.

372.9

BCTC is a potent and selective antagonist of TRPV1 channels, shown to inhibit capsaicin-, pH- and PKC-induced responses of mouse TRPV1 with IC50 of 1.3, 0.59 and 0.37 nM, respectively.1,2 BCTC is also a blocker of TRPM8 channels, inhibiting rat TRPM8-mediated menthol and cold-evoked Ca2+ response with IC50 of 0.6 µM.3

1-10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

1 nM – 100 nM.

Lyophilized

N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide

C20H25ClN4O.

393514-24-4

Up to four weeks at 4°C or three months at -20°C.