Polymyxin B1

A cationic peptide antibiotic

The polymyxins are cationic peptides originally isolated from B. polymyxa.1 They bind and kill Gram-negative bacteria.2 The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B1 is a form of polymyxin B which terminates with 6-methyloctanamide. Polymyxin B1 is comparable to other B polymyxins in its ability to kill P. aeruginosa, A. baumannii, and K. pneumoniae isolates.3 Its relative pharmacokinetics and nephrotoxicity have not been examined.

1203.5

≥95%

O=C([C@@H](NC([C@H](CCN)NC(CCCC[C@@H](C)CC)=O)=O)[C@@H](C)O)N[C@@H](CCN)C(N[C@@H](CCNC([C@@H](NC([C@@H](NC([C@H](CCN)N1)=O)CCN)=O)[C@H](O)C)=O)C(N[C@@H](CCN)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C1=O)=O)=O)=O)=O

C56H98N16O13

4135-11-9

≥ 4 years

1N HCl: 10 mg/ml

1.Falagas, M.E. and Kasiakou, S.K. Toxicity of polymyxins: A systematic review of the evidence from old and recent studies. Critical Care 10(1), (2006).
2.Hancock, R.E.W. Cationic peptides: Effectors in innate immunity and novel antimicrobials. Lancet Infect.Dis. 1(3), 156-164 (2001).
3.Tam, V.H.,Cao, H.,Ledesma, K.R., et al. In vitro potency of various polymyxin B components. Antimicrobial Agents and Chemotherapy 55(9), 4490-4491 (2011).