Arachidonic Acid

An ω-6 PUFA; precursor of eicosanoids

Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways.1 Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release, metabolism, and re-uptake of free arachidonate are all important aspects of cell signaling and inflammation.2

304.5

≥98%

5Z，8Z，11Z，14Z二十碳四烯酸≥98%杂质≤2%

AA|FA 20:4

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O

C20H32O2

506-32-1

≥ 2 years

0.1 M Na2CO3: 1.7 mg/ml DMF: 100 mg/ml DMSO: 100 mg/ml Ethanol: Miscible

1.Nixon, A.B.,Greene, D.G., and Wykle, R.L. Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophils. Biochimica et Biophysica Acta 1300, 187-196 (1996).
2.Burgoyne, R.D., and Morgan, A. The control of free arachidonic acid levels. Trends in Biochemical Sciences 15, 365-366 (1990).

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