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产品介绍
产品信息
宿主
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产品详情
CM Sepharose Fast Flow is a weak cation exchanger based on the well established Sepharose Fast Flow ion exchange platform, extensively used for preparative protein separations in both research and industrial applications.Well-proven weak cation exchanger developed for industrial downstream processesUsed extensively for capture and intermediate purification of a wide range of approved biopharmaceuticalsThe industry standard for ion exchange chromatography during recent decadesHigh chemical stability allows for well proven CIP and sanitization protocolsThe hydrophilic nature of the base matrix ensures low levels of non-specific binding leading to low levels of host cell-derived impurities in the elution pool.CM Sepharose Fast Flow is part of the Sepharose Fast Flow ion exchange platform, which has been the industrial standard for ion exchange chromatography during recent decades. It is composed of cross-linked, 6% agarose particles, with carboxymethyl (CM) weak cation exchange groups. CM Sepharose Fast Flow has high chemical stability, allowing well proven cleaning-in-place (CIP) and sanitization protocols. Scale-up with CM Sepharose Fast Flow is straight forward and the resin is available in a range of pre-packed process development tools.As member of the BioProcess resin range, CM Sepharose Fast Flow meets industrial demands with security of supply and comprehensive technical and regulatory support.
产品用途
CM Sepharose Fast Flow is a weak cation exchanger based on the well established Sepharose Fast Flow ion exchange platform, extensively used for preparative protein separations in both research and industrial applications.

商品描述
CM Sepharose Fast Flow
CM Sepharose Fast Flow is a weak cation exchanger based on the well established Sepharose Fast Flow ion exchange platform, extensively used for preparative protein separations in both research and industrial applications.

产品参数
- BioProcess resinYes
- Chemical stabilityStable to commonly used aqueous buffers:1.0 M NaOH, 8 M urea, 8 M guanidine hydrochloride, 70% ethanol
- Exclusion limit (Mr) (globular proteins)~4 × 10⁶
- Ion Exchanger TypeWeak cation exchanger
- Ionic Capacity0.09-0.13 mmol H+/ml medium
- LigandCarboxymethyl
- Matrixcross-linked agarose, 6%, spherical
- Particle Size45 μm-165 μm
- Particle size, d50V~90 µm
- Pressure/Flow Specification300-600 cm/h, 100 kPa, XK 50/30 column, bed height 15 cm
- Storage4 to 30°C, 20% Ethanol
- pH ligand fully chargedAbove 6
- pH stability, CIP2–14
- pH stability, operational4–13
组成成分
100%高交联改性天然聚合物琼脂糖(固体) ,悬浮于含14-19%乙醇,81-86%水的溶液中

背景
CAS号
64-17-5

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