ent-Prostaglandin E2

Ent-Prostaglandin E2 is the enantiomer of enzymatically-derived prostaglandin E2 (PGE2; sc-201225). Both are optically pure compounds whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Significant amounts of racemic PGE2 are created in vitro in settings of oxidative stress via isoprostane pathway intermediates. Inhibition of COX-2 with Aspirin (sc-202471) reportedly reduces thromboxane A2 synthesis by 90% and PGI2 by > 80%, however, the same concentration decreases PGE2 by only 60%; this may be at least partially explained by free radical-catalyzed formation of stereoisomers of PGE2. Ent-Prostaglandin E2 could potentially be used as an analytical standard in the deconvolution of these extremely relevant, but complex biochemical issues. 参考文献 1. Gao, L., et al. 2003. J. Biol. Chem. 278: 28479-28489. PMID: 12746435

352.5

干冰

ent-Prostaglandin E2 is the enantiomer of PGE2

Enantiomeric PGE2

CCCCC[C@@H]​(O)​/C=C/C1C(O)​CC(=O)​[C@H]​1C/C=C\CCCC(=O)​O

C20H32O5

65085-69-0