Tetrahydrobiopterin (THB) dihydrochloride

Tetrahydrobiopterin (THB) dihydrochloride is an activating Nitric Oxide Synthase (NOS) cofactor used in a variety of applications. THB is also a known cofactor for the monooxygenases that hydroxylate phenylalanine, tyrosine, and tryptophan. Synthesis of THB has been documented to be the rate limiting step in the metabolism of phenylalanine and the biosynthesis of neurotransmiter amines. In mice, Quinolinic acid (sc-203226) induced convulsions that were potentiated with Tetrahydrobiopterin dihydrochloride, demonstrating that endogenous NO may be involved in stimulating the NMDA receptors. When hypertensive mice were fed THB but were not introduced to hydralazine or tetrahydroneopterin, they displayed improved cardiac THB stores, phosphorylated phospholamban levels, and diastolic dysfunction. THB has also been observed as an essential cofactor in the hydroxylation process in mammalian brains. 参考文献 1. Kwon, N.S., et al. 1989. J. Biol. Chem. 264: 20496-20501. PMID: 25842262. Ortega, T.M., et al. 1994. Nutr Hosp. 9: 251-256. PMID: 79187913. Schallreuter, K.U., et al. 1994. Science. 263: 1444-1446. PMID: 81282284. Nakamura, T.A., et al. 1995. Pharmacol. Biochem. Behav. 51: 309-312. PMID: 76673455. Silberman, G.A., et al. 2010. Circulation. 121: 519-528. PMID: 20083682

314.17

powder

≥98% 四氢生物蝶呤（THB）二盐酸盐

Tetrahydrobiopterin (THB) dihydrochloride is an activating Nitric Oxide Synthase cofactor used in a variety of applications.

Tetrahydrobiopterin (THB) dihydrochloride is known as an activating NOS cofactor.

C[C@@H]([C@@H]([C@H]1CNC2=C(N1)C(=O)N=C(N2)N)O)O.Cl.Cl

C9H15N5O3•2HCl

69056-38-8