Artemether

An antiparasitic compound

Artemether is an antiparasitic compound and a derivative of artemisinin (Item No. 11816).1 It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively).2 Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively.3 It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg.1 Formulations containing artemether have been used in the treatment of malaria.

298.4

≥98%

(+)-Artemether|SM-224

CO[C@H]1O[C@@]2([H])[C@]3(OO4)[C@](CC[C@@H](C)[C@]3([H])CC[C@]4(C)O2)([H])[C@H]1C

C16H26O5

71963-77-4

≥ 4 years

DMF: 20 mg/ml DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml DMSO: 10 mg/ml Ethanol: 16 mg/ml

1.Akoachere, M.,Buchholz, K.,Fischer, E., et al. In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins. Antimicrobial Agents and Chemotherapy 49(11), 4592-4597 (2005).
2.Pradines, B.,Ramiandrasoa, F.,Basco, L.K., et al. In vitro activities of novel catecholate siderophores against Plasmodium falciparum. Antimicrobial Agents and Chemotherapy 40(9), 2094-2098 (1996).
3.Mayxay, M.,Khanthavong, M.,Chanthongthip, O., et al. Efficacy of artemether-lumefantrine, the nationally-recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern Laos. Malar.J. 11(1), 1-17 (2012).
4.Liu, R.,Dong, H.F.,Guo, Y., et al. Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: A systematic review and meta-analysis. Parasit.Vectors 4, 1-17 (2011).
5.Ghantous, A.,Gali-Muhtasib, H.,Saliba, N.A., et al. What made sesquiterpene lactones reach cancer clinical trials? Drug Discovery Today 15(15-16), 668-678 (2010).