Wnt Agonist

Wnt Agonist is a cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling. Wnt Agonist functions best at an IC50 > 60 μM. In addition to mimicking the effect of Wnt, Wnt Agonist has also induced β-catenin and T-cell fate-dependent transcriptional activity in HEK-293T cells at an EC50 = 700 nM. When applied to Xenopous embryos, Wnt Agonist caused substantial head defects development. Wnt Agonist has also been observed to enhance beta cell expansion in vitro. Wnt Agonist is beneficial for studying the effects of Wnt pathway, due to the activation of Wnt without inhibiting the activity of GSK-3β. 参考文献 1. Gazit, A., et al. 1999. Oncogene. 18: 5959-5966. PMID: 105570842. Liu, Jun., et al., 2005. A small-molecule agonist of the Wnt signaling pathway. Angewandte Chemie (International ed. in English). 44(13): 1987-90. PMID: 157242593. Li, S., et al. 2008. Differentiation. 76: 897-907. PMID: 184525494. Lal, M., et al. 2008. Hum. Mol. Genet. 17: 3105-3117. PMID: 186326825. Wang, W., et al. 2009. Proc. Natl. Acad. Sci. U.S.A. 106: 1427-1432. PMID: 19164755

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Wnt Agonist is a cell-permeable pyrimidine that functions as a potent and selective activator of Wnt signaling.

Wnt Agonist is also known as BML-284.

COC1=CC=CC(=C1)C2=CC(=NC(=N2)N)NCC3=CC4=C(C=C3)OCO4

C19H18N4O3

853220-52-7