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ACO2 (D6D9) XP ® Rabbit mAb

品牌： CST

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参数

分子量：

反应种属：

Human,Mouse,Rat,Hamster,Monkey,

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产品介绍

产品信息

抗原名称

ACO2

来源纯化

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly540 of human ACO2 protein.

宿主

Rabbit

简单描述

Monoclonal Antibody for studying ACO2. Cited in 17 publications. Validated for WB, IP, IF. Available in 2 sizes. Highly specific and rigorously validated in-house, ACO2 (D6D9) XP® Rabbit Monoclonal Antibody (CST #6571) is ready to ship.

商品描述

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:50
Immunofluorescence (Immunocytochemistry)	1:200

分子量

研究领域

癌症,细胞生物学,纤维化,代谢,神经科学

应用

反应种属

Human,Mouse,Rat,Hamster,Monkey,

目标/特异性

Specificity/Sensitivity

ACO2 (D6D9) XP® Rabbit mAb recognizes endogenous levels of total ACO2 protein.

Species Reactivity:

Human, Mouse, Rat, Hamster, Monkey

敏感性

Endogenous

背景

Aconitase 2 (ACO2) catalyzes the conversion of citrate to isocitrate via cis-aconitate in the second step of the tricarboxylic acid (TCA) cycle (1,2). ACO2 is also an important regulator of iron homeostasis within cells (1-4). In addition, research studies have shown that this enzyme is deficient in the mitochondrial disease Friedreich's Ataxia (4,5). 1.Gille, G. and Reichmann, H. (2011) J Neural Transm 118, 349-59. 2.Mirel, D.B. et al. (1998) Gene 213, 205-18. 3.Myers, C.R. et al. (2010) Free Radic Biol Med 49, 1903-15. 4.Rötig, A. et al. (1997) Nat Genet 17, 215-7. 5.Ye, H. and Rouault, T.A. (2010) Biochemistry 49, 4945-56.

研究领域

癌症,细胞生物学,纤维化,代谢,神经科学

翻译后修饰

Unmodified

制备和贮存

保存方式

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

数据库链接

Entrez-Gene ID

UniProt ID

Q99798

参考图片

Western blot analysis of extracts from various cell lines using ACO2 (D6D9) XP^®Rabbit mAb.

Confocal immunofluorescent analysis of HeLa cells using ACO2 (D6D9) XP^® Rabbit mAb (green), showing colocalization with mitochondria that were labeled with MitoTracker^® Red CMXRos (red). Blue pseudocolor = DRAQ5^® #4084 (fluorescent DNA dye).

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货号：

6571T

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20ul

100ul

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