ALS-8112

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ALS-8112

品牌： Absin

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参数

分子式：

C₁₀H₁₃ClFN₃O₄

分子量：

293.68

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产品介绍

产品信息

抗原名称

RSV

商品描述

ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5‘-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM.

分子量

293.68

纯度

98%

可溶性

DMSO: ≥ 47 mg/mL

In vitro(体外研究)

The 5'-triphosphate form of ALS-8112 (ALS-8112-TP) is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis. ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours. The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination. ALS-8112 is a pan-strain inhibitor of RSV replication in vitro. The RNA transcription activity of the RSV–RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC50 of 0.020 ± 0.008 μM.

背景

分子式

C₁₀H₁₃ClFN₃O₄

CAS号

1445379-92-9

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs818536-5mg

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询价

5mg

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