Anti-CACNA1G (CaV3.1) Antibody

Voltage-dependent Ca²⁺ channels provide a pathway for rapid influx of Ca²⁺ into cells, which plays a crucial role in both electrical and metabolic signaling.¹ 

T-type currents are transduced via channel proteins encoded by three genes that compose a subfamily within the Cav channel family.^2-3 

The activity of T-type channels contributes to several known physiological and pathophysiological phenomena including burst firing in neurons, pace making activity in the heart and secretion  
from endocrine tissues.² There are three cloned T-type channel isoforms.  

Ca_V3.1 (α1G) and Ca_V3.2 (α1H) are widely distributed whereas the expression of Ca_V3.3 (α1I) is restricted to the central nervous system.²

Ca_V3.1 and Ca_V3.2 are also expressed in the kidney, but little is known about their physiological role there.