Anti-KCNH7 (erg3) Antibody

K_v11.3 (erg3) is a member of the ether-a-go-go (EAG) subfamily of voltage-dependent K⁺ channels. The erg subfamily includes the closely related proteins K_v11.1 (erg1) and K_v11.2 (erg2) that possess the signature structure of the voltage-dependent K⁺ channels: six membrane-spanning domains with intracellular N and C termini. As with all voltage-dependent K⁺ channels the functional channel is a tetramer composed of four subunits. It has been suggested that the K_v11 subfamily members can form functional heteromultimers within the subfamily.
 
The current of the K_v11.1 and K_v11.2 channels is that of a strong inward rectifier with slow activating kinetics. The K_v11.3 channel has different biophysical properties: it is a weak inward rectifier that is activated at negative potentials and has rapid activating kinetics.
 
K_v11.3 expression is believed to be concentrated mainly in the brain with the stronger expression detected in the cerebral cortex and hippocampus.
 
At the moment there is not much pharmacological information concerning K_v11.3 modulation, but the channel has been shown to be inhibited (as are all K_v11 subfamily members) by the anti-arrhythmic E-4031 as well as by the anti-psychotic drugs sertindole and pimozide.