Artesunate

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Artesunate

品牌： Absin

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参数

分子式：

C₁₉H₂₈O₈

分子量：

384.42

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产品介绍

产品信息

抗原名称

EXP1(a membrane glutathione S-transferase),STAT3

商品描述

Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. Artesunate is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection. Artesunate is used primarily as treatment for malaria; but artesunate has also been shown to be >90% efficacious at reducing egg production in Schistosoma haematobium infection.

分子量

384.42

纯度

＞98%

可溶性

DMSO : 71 mg/mL (184.7 mM)
Ethanol : 71 mg/mL (184.7 mM)

外观

类白色粉末

In vitro(体外研究)

ART could alter the biomechanical properties of the glioma cells to inhibit cell proliferation, migration and invasion .The ART significantly suppresses the cell proliferation, induces the apoptosis and promoted cell cycle arrest at G0/G1 phase in SKM-1 cells. The mechanisms of ART anti-MDS is associated with the increase of intracellular calciumion concentration and ROS levels. In addition, the pro-apoptotic activity of ART may be involved in the regulation of BCL-2 /BAX ratio and the expressions of P-bad and survivin. ART treatment demethylates CDH1, which, in turn recovers the E-cadherin activation in SKM-1 cells.

In vivo(体内研究)

Artesunate is a medication used to treat malaria. Artesunate can induce radiosensitivity of HeLa cells in vivo using Xenograft model of nude mice. Artesunate had a relatively high immunosuppressive activity with low toxicity, and could inhibit T lymphocyte proliferation induced by mitogen and alloantigen.

背景

别名

青蒿酯、青蒿琥酯

分子式

C₁₉H₂₈O₈

CAS号

88495-63-0

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs816675-10mg

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