一 产品介绍
神经节苷脂GD2在神经外胚层起源的肿瘤上表达，包括人神经母细胞瘤和黑色素瘤。GD2的肿瘤特异性表达使其成为用单克隆抗体或人工T细胞受体进行免疫治疗的合适靶标。克隆号14G2a是选自亲本产生IgG3的杂交瘤14.18的同种型开关变体，并且具有与亲本抗体相同的反应性。
二 产品详情
| 产品货号 | BE0318 |
| 产品规格 | 1/5/25/50/100mg |
| 抗体亚型 | Mouse IgG2a, κ |
| 推荐同型对照 | InVivoMAb mouse IgG2a isotype control, unknown specificity（货号：BE0085） |
| 推荐抗体稀释液 | InVivoPure™ pH7.0 Dilution Buffer（货号：IP0070） |
| 免疫原 | Neuroblastoma cell line LAN-1 |
| 应用 | in vitro induction of apoptosis in GD2+ cells in vivo inhibition of GD2+ tumor cell growth |
| 产品形式 | PBS , pH 7.0 Contains no stabilizers or preservatives |
| 内毒素水平 | <2EU/mg (<0.002EU/μg) |
| 纯度 | >95% Determined by SDS-PAGE |
| 无菌处理 | 0.2 μM filtered |
| 生产形式 | 从组织培养上清液中纯化得到。 |
| 纯化形式 | Protein A |
| RRID | AB_2819045 |
| 分子量大小 | 150 kDa |
| 保存条件 | 抗体原溶液应保存在4°C条件下，不要冷冻保存。 |
三 已发表文献
| 用途 | 已发表文献 |
| in vitro induction of apoptosis in GD2+ cells | Durbas, M., et al. (2018). “GD2 ganglioside-binding antibody 14G2a and specific aurora A kinase inhibitor MK-5108 induce autophagy in IMR-32 neuroblastoma cells.” Apoptosis 23(9-10): 492-511 |
| in vitro induction of apoptosis in GD2+ cells | Kowalczyk, A., et al. (2009). “The GD2-specific 14G2a monoclonal antibody induces apoptosis and enhances cytotoxicity of chemotherapeutic drugs in IMR-32 human neuroblastoma cells.” Cancer Lett 281(2): 171-182. |
| in vitro induction of apoptosis in GD2+ cells | Mujoo, K., et al. (1989). “Functional properties and effect on growth suppression of human neuroblastoma tumors by isotype switch variants of monoclonal antiganglioside GD2 antibody 14.18.” Cancer Res 49(11): 2857-2861 |
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