BioXcell特色产品推荐之：InVivoMAb anti-mouse/rat IL-1β（B122）

一、产品介绍
IL-1β是炎症反应的重要介质，参与多种细胞活动，包括细胞增殖、分化、凋亡以及T和B淋巴细胞活化。IL-1由IL-1α和IL-1β组成，它们是不同基因的产物，但被两种不同的IL-1受体识别。IL-1受体I型，一种80kDa的跨膜蛋白，具有IL-1信号传导功能；IL-1受II型，一种68kDa的膜蛋白，具有相对较短的细胞质尾II型受体作为IL-1的诱饵靶，通过阻止IL-1与II型受体的结合来抑制IL-1的活性。据报道，B122抗体可中和天然或重组IL-1β的生物活性

二、产品详情

产品详情
产品货号	BE0246
产品规格	1/5/25/50/100mg
抗体亚型	Armenian Hamster IgG
推荐同型对照	InVivoMAb polyclonal Armenian hamster IgG（货号：BE0091）
推荐抗体稀释液	InVivoPure™ pH 7.0 Dilution Buffer（货号：IP0070）
免疫原	Recombinant mouse IL-1β
应用	in vivo IL-1β neutralization、in vitro IL-1β neutralization、ELISA
产品形式	PBS , pH 7.0 Contains no stabilizers or preservatives
内毒素水平	<2EU/mg (<0.002EU/μg)使用 LAL gel clotting 测定
纯度	>95% Determined by SDS-PAGE
无菌处理	0.2 μM filtered
生产形式	从组织培养上清液中纯化得到。
纯化形式	Protein G
RRID	AB_2687727
分子量大小	150 kDa
保存条件	抗体原溶液应保存在4°C条件下，不要冷冻保存。

三、已发表文献

用途	已发表文献
in vivo IL-1β neutralization	Coffelt, S. B., et al. (2015). “IL-17-producing gammadelta T cells and neutrophils conspire to promote breast cancer metastasis.” Nature 522(7556): 345-348
in vivo IL-1β neutralization	Copenhaver, A. M., et al. (2015). “IL-1R signaling enables bystander cells to overcome bacterial blockade of host protein synthesis.” Proc Natl Acad Sci U S A 112(24): 7557-7562
in vivo IL-1β neutralization	Hernandez, P. P., et al. (2015). “Interferon-lambda and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.” Nat Immunol 16(7): 698-707
in vivo IL-1β neutralization	Lawlor, K. E., et al. (2015). “RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.” Nat Commun 6: 6282
in vivo IL-1β neutralization	Russell, R. F., et al. (2015). “Partial Attenuation of Respiratory Syncytial Virus with a Deletion of a Small Hydrophobic Gene Is Associated with Elevated Interleukin-1beta Responses.” J Virol 89(17): 8974-8981
in vivo IL-1β neutralization	Chen, K. W., et al. (2014). “The neutrophil NLRC4 inflammasome selectively promotes IL-1beta maturation without pyroptosis during acute Salmonella challenge.” Cell Rep 8(2): 570-582
in vivo IL-1β neutralization	Gopinath, S., et al. (2014). “Role of disease-associated tolerance in infectious superspreaders.” Proc Natl Acad Sci U S A 111(44): 15780-15785.
in vivo IL-1β neutralization	Khmaladze, I., et al. (2014). “Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice.” Proc Natl Acad Sci U S A 111(35): E3669-3678.
in vivo IL-1β neutralization	Botelho, F. M., et al. (2011). “IL-1alpha/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice.” PLoS One 6(12): e28457
in vivo IL-1β neutralization	Gonzalez-Navajas, J. M., et al. (2010). “Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.” J Exp Med 207(13): 2799-2807.
in vivo IL-1β neutralization	Gekara, N. O., et al. (2009). “Signals triggered by a bacterial pore-forming toxin contribute to toll-like receptor redundancy in gram-positive bacterial recognition.” J Infect Dis 199(1): 124-133.

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