BioXcell特色产品推荐之： InVivoMAb anti-mouse/human/rat/monkey/hamster/canine/bovine TGF-β

一产品介绍
TGF-β 是一种多功能细胞因子，可调节上皮细胞增殖细胞、内皮细胞、成纤维细胞、神经元、淋巴样细胞（包括 T 淋巴细胞和 NK 细胞）以及其他造血细胞类型。TGF-β 还调节活化巨噬细胞的活性和调节性 T 细胞的发育。此外，TGF-β 在免疫功能、组织重塑和伤口修复中发挥作用。TGF-β 以五种高度相似的亚型 (TGF-β 1-5) 存在，同源性为 70-80%。TGF-β1 是通过酶切由 TGFB1 基因编码的长前体 TGF-β1 多肽合成的，该基因产生成熟蛋白和潜伏相关肽 (LAP)。LAP 和成熟的 TGF-β1 在分泌过程中非共价结合。TGF-β 由许多细胞类型普遍表达，包括表达高水平 TGF-β 的巨噬细胞和血小板。TGF-β 信号已被证明在癌症、自身免疫性疾病、哮喘、心脏病和糖尿病中发挥作用。TGF-β 基因敲除小鼠显示出造血功能和内皮细胞分化缺陷，并死于压倒性炎症，说明了其重要性。1D11.16.8单克隆抗体是一种中和抗体。TGF-β 基因敲除小鼠显示出造血功能和内皮细胞分化缺陷，并死于压倒性炎症，说明了其重要性。1D11.16.8单克隆抗体是一种中和抗体。TGF-β 基因敲除小鼠显示出造血功能和内皮细胞分化缺陷，并死于压倒性炎症，说明了其重要性。1D11.16.8单克隆抗体是一种中和抗体。

二产品详情

产品详情
产品编号	BE0057
同型	Mouse IgG1，κ
推荐的同种型对照	InVivo MAb mouse IgG1 同种型对照
推荐的稀释缓冲液	InVivo Pure pH 7.0 稀释缓冲液
免疫原	Bow TGFβ 2
产品应用用途	体内TGFβ 中和、体外TGFβ 中和Western blot
产品组分	PBS，pH 7.0不含稳定剂或防腐剂
内毒素	<2EU/mg (<0.002EU/μg)通过 LAL 试验测定
纯度	>95%由 SDS-PAGE 确定
无菌性	0.2 μM 过滤
生产	在无动物设施中从组织培养上清液中纯化
纯化	Protein G
RRID	AB_1107757
分子量	150 kDa
贮存	抗体溶液应在 4°C 下以原液浓度储存

三已发表文献

用途	已发表文献
in vivo TGFβ neutralization	Komai, T., et al. (2018). "Transforming Growth Factor-beta and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals" Front Immunol 9: 1364
in vivo TGFβ neutralization	Clemente-Casares, X., et al. (2016). "Expanding antigen-specific regulatory networks to treat autoimmunity" Nature 530(7591): 434-440
in vivo TGFβ neutralization	Manlove, L. S., et al. (2015). "Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells" J Immunol
in vivo TGFβ neutralization	Bodogai, M., et al. (2015). "Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells" Cancer Res 75(17): 3456-3465.
in vivo TGFβ neutralization	Choi, Y. S., et al. (2015). "LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6" Nat Immunol 16(9): 980-990
in vivo TGFβ neutralization	Greco, S. H., et al. (2015). "TGF-beta Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer Cachexia" PLoS One 10(7): e0132786
in vivo TGFβ neutralization	Leon, B., et al. (2014). "FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability" Nat Commun 5: 3495.
in vivo TGFβ neutralization	Li, W., et al. (2014). "Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis" J Clin Invest 124(2): 755-767
in vivo TGFβ neutralization	Worthington, J. J., et al. (2013). "Loss of the TGFbeta-activating integrin alphavbeta8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity" PLoS Pathog 9(10): e1003675
in vivo TGFβ neutralization	Ring, S., et al. (2013). "Targeting of autoantigens to DEC205(+) dendritic cells in vivo suppresses experimental allergic encephalomyelitis in mice" J Immunol 191(6): 2938-2947
in vivo TGFβ neutralization	Tai, N., et al. (2013). "TLR9 deficiency promotes CD73 expression in T cells and diabetes protection in nonobese diabetic mice" J Immunol 191(6): 2926-2937
in vivo TGFβ neutralization	Kurkjian, C., et al. (2012). "Alveolar macrophages in neonatal mice are inherently unresponsive to Pneumocystis murina infection" Infect Immun 80(8): 2835-2846.
in vivo TGFβ neutralization	Garidou, L., et al. (2012). "Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection" J Virol 86(13): 7060-7071

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