CBA应用之自身免疫疾病

指标	样本来源	文献名称	仪器	相关
CXCL10	human Plasma	Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity	BD FACSCalibur	红斑狼仓炎症
Th1 (IL-2, TNF-a, IFN-g) and Th2 (IL-4, IL-5, IL-10)	supernatants (50 ml)	CD4 C CD25 high regulatory T cells in human autoimmune diabetes	/	自身免疫性糖尿病
IL-1β,IL-6, IL-8, and IL-10	Culture supernatants	Expression of Toll-Like Receptor 2 on CD16+Blood Monocytes and Synovial Tissue Macrophages in Rheumatoid Arthritis	BD FACScan	类风湿性关节炎
IL-1β, IL-6, IL-8, IL-10, IL-12p70, TNF-α	monocyte culture supernatants	The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis	BD FACScan	类风湿性关节炎
IFN-γ,TNF-α,IL-8,IL-6,IL-17	Culture supernatants	A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs	/	SLA系统性红斑狼疮
IL-8, IL-1, IL-6, IL-10, TNF-α, and IL-12p70	sera and supernatant samples	Aberrant Phenotype and Function of Myeloid Dendritic Cells in Systemic Lupus Erythematosus	BD FACSCalibur	SLA系统性红斑狼疮
IFN-γ	Culture supernatants	Deficient CD4+CD25high T Regulatory Cell Function in Patients with Active Systemic Lupus Erythematosus	BD FACSCalibur	SLA系统性红斑狼疮
TNF-α	serum and macrophage culture supernatant	Systemic lupus erythematosus-associated defects in the inhibitory receptor Fcγ RIIb reduce susceptibility to malaria	BD FACSCalibur	SLA系统性红斑狼疮
IL-6, IL-10,MCP-1,IFN-γ, TNF,IL-12p70	Culture supernatants	NKT Cell-Dependent Amelioration of a Mouse Model of Multiple Sclerosis by Altering Gut Flora	BD FACSCalibur	多发性硬化症
IP-10, RANTES protein secretion	cellsupernatant	Exogenous IFN-b has antiviral and anti-inflammatory properties inprimary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus	BD FACAria	哮喘炎症
C3a/C3a desArg, C4a/C4a desArg, and C5a/C5a desArg	sputum supernatant	Complement Factors C3a, C4a, and C5a in Chronic Obstructive Pulmonary Disease and Asthma	BD FACSCalibur	哮喘炎症
IL-6, IL-10,IFN-γ,TNF-α , and CCL2	Culture supernatants	CCR5-Deficient Mice Develop Experimental Autoimmune Uveoretinitis in the Context of a Deviant Effector Response	BD FACSCalibur	自身免疫性疾病

指标	alpha-1 anti-trypsin, alpha-2 macroglobulin,β-2 microglobulin, brain-derived neurotrophic factor, C-reactive protein, complement 3,eotaxin,factor VII, ferritin, fibrinogen, granulocyte-macrophagecolony-stimulatingfactor,haptoglobin,intercellular adhesion molecule-1,IFN-γ, IL-1α, IL-1β, IL-1,IL-1RA, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-12p70, IL-15, IL-17A, IL-18,IL-23,MMP2, MMP3, MMP9,MIP-1, MIP-1β,MCP-1,RANTES,stem cell factor, tissue inhibitor of metalloproteinase,IFN-γ,TNF-α, vascular cellular adhesion molecule type 1, vascular endothelial growth factor, vWF and vitamin D binding protein
样本来源	patient plasma samples
文献名称	The Pharmacodynamic Impact of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, on Circulating Levels of Inflammatory Biomarkers in Patients with Psoriatic Arthritis: Substudy Results from a Phase III, Randomized, Placebo-Controlled Trial (PALACE 1)
仪器	/
相关	牛皮癣关节炎-给药评价