Hu B7-H6 BV421 1A5 25Tst

Human B7-H6 Transfected Cell Line

The 1A5 monoclonal antibody specifically recognizes B7 homolog 6 (B7-H6). B7-H6 is a ~51 kDa type I transmembrane glycoprotein that is encoded by NCR3LG1 (natural killer cell cytotoxicity receptor 3 ligand 1) which belongs to the B7 family of immunoreceptors. B7-H6 contains one IgV-like and one IgC1-like domain in its extracellular region followed by a transmembrane region and an intracytoplasmic region with an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an SH2- and SH3-binding motifs. Although B7-H6 is not expressed by normal cells from healthy individuals, it is variably expressed on stressed cells including tumor cells and tumor cell lines, and can be moderately expressed on proinflammatory monocytes and neutrophils. Binding of B7-H6 to CD337 (NKp30/NCR3) induces NK cell activation, cytotoxicity, and cytokine secretion which suggests it may play an important role in immunosurveillance against certain tumors and infectious diseases.

5 µl/test

Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.

研发参考(3) 1. Brandt CS, Baratin M, Yi EC, et al. The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans.. J Exp Med. 2009; 206(7):1495-503. (Biology). 2. Matta J, Baratin M, Chiche L, et al. Induction of B7-H6, a ligand for the natural killer cell-activating receptor NKp30, in inflammatory conditions.. Blood. 2013; 122(3):394-404. (Biology). 3. Wang R, Jaw JJ, Stutzman NC, Zou Z, Sun PD. Natural killer cell-produced IFN-γ and TNF-α induce target cell cytolysis through up-regulation of ICAM-1.. J Leukoc Biol. 2012; 91(2):299-309. (Clone-specific: Flow cytometry).

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