BAY 87-2243

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BAY 87-2243

品牌： Absin

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参数

分子式：

C₂₆H₂₆F₃N₇O₂

分子量：

525.53

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产品介绍

产品信息

抗原名称

HIF-1

商品描述

BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I.

分子量

525.53

纯度

>98%

可溶性

DMSO : 25 mg/mL (47.57 mM; Need ultrasonic)

外观

White solid

In vitro(体外研究)

BAY 87-2243 inhibits HIF-1 reporter gene activity and CA9 protein expression with IC50 of 0.7 nM and 2 nM, respectively. In hypoxic lung cancer H460 cells, BAY 87-2243 suppresses HIF target gene expression, and inhibits HIF-1α protein accumulation. Under glucose depletion, BAY 87-2243 inhibits cell proliferation via interference with mitochondrial function.

In vivo(体内研究)

In H460 xenograft mouse model, BAY 87-2243 (4 mg/kg p.o.) reduces tumor weight, HIF-1α protein, and HIF-1 target gene expression levels.

背景

分子式

C₂₆H₂₆F₃N₇O₂

CAS号

1227158-85-1

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs811256-10mg

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