Bay K 8644

1/2

Bay K 8644

品牌： Absin

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参数

分子式：

C₁₆H₁₅F₃N₂O₄

分子量：

356.30

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产品介绍

产品信息

抗原名称

L-type calcium channel

商品描述

Bay K 8644 is a potent, selective activator of L-type Ca²⁺ channel with IC₅₀ of 17.3 nM.

分子量

356.30

纯度

98%

可溶性

DMSO ：71mg/mL(199.27mM)
Ethanol ：71mg/mL(199.27mM)

外观

Yellow solid

In vitro(体外研究)

It was demonstrated that Bay K 8644 prolonged the mean Ca²⁺ channel opening time in heart myocytes and neurones of spinal ganglia. An experiment using rat heart ventricles demonstrated that Bay K 8644, at the final concentration of approximately 1 pM, had strong positive inotropic effect when added to the perfusion fluid. Moreover, the addition of Bay K 8644 to the chronic ethanol treatment significantly reduced the electrophysiological signs of withdrawal in the isolated hippocampal slices.

In vivo(体内研究)

Study in mice demonstrated that Bay K 8644 significantly ameliorated the ethanol withdrawal syndrome. When experimental animals were administered with an acute injection of Bay K 8644, the convulsive behavior of mice could be monitored to increase for 2 hours. In addition, BAY k 8644 was also reported to ameliorate hypotension in endotoxin-shocked rats. It could lead to a 37% decrease in heart rate of endotoxin-treated rats and 39% decrease in control rats in a dose-dependent manner.

背景

分子式

C₁₆H₁₅F₃N₂O₄

CAS号

71145-03-4

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs816169-5mg

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