BFH772

1/2

BFH772

品牌： Absin

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参数

分子式：

C₂₃H₁₆F₃N₃O₃

分子量：

439.39

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产品介绍

产品信息

抗原名称

VEGFR2

商品描述

BFH772 is a potent oral VEGFR2 inhibitor, which is highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM.

分子量

439.39

纯度

>98%

可溶性

DMSO : 100 mg/mL (227.59 mM; Need ultrasonic)

In vitro(体外研究)

BFH772 was highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM, however, lost 500-fold potency on FLK-1, FLT-1, and FLT-4. BFH772 was highly selective, In addition to VEGFR2, it also targeted B-RAF, RET, and TIE-2, albeit with at least 40-fold lower potency. BFH772 inhibits the ligand induced autophosphorylation of RET, PDGFR, and KIT kinases, with IC50 values ranging between 30 and 160 nM.

In vivo(体内研究)

BFH772 all at 3 mg/kg orally dosed once per day potently inhibited melanoma growth (by 54−90% for primary tumor and 71−96% for metastasis growth).

背景

分子式

C₂₃H₁₆F₃N₃O₃

CAS号

890128-81-1

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs813329-10mg

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