BIX 02189 (10 mg)

46931012

Selective MEK5 and ERK5 inhibitor

440.54

(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide

Selective MEK5 and ERK5 inhibitor (IC₅₀ values are 1.5 and 59 nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells.

≥98% (HPLC)

Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl

O=C2NC1=CC(C(N(C)C)=O)=CC=C1/C2=C(C4=CC=CC=C4)/NC3=CC(CN(C)C)=CC=C3

C₂₇H₂₈N₄O₂

1265916-41-3