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Caspase-8 (D35G2) Rabbit mAb

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Caspase-8 (D35G2) Rabbit mAb

品牌： CST

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参数

分子量：

10, 57

反应种属：

Human,Mouse,Rat,

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产品介绍

产品信息

抗原名称

Caspase-8

来源纯化

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxyl terminus of human caspase-8 protein.

宿主

Rabbit

简单描述

Monoclonal Antibody for studying Casp8. Cited in 311 publications. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Caspase-8 (D35G2) Rabbit Monoclonal Antibody (CST #4790) is ready to ship.

商品描述

Product Usage Information

Application	Dilution
Western Blotting	1:1000

分子量

10, 57

内毒素水平

猪

研究领域

癌症,细胞生物学,纤维化,神经科学,

应用

反应种属

Human,Mouse,Rat,

预测反应种属

Pig

目标/特异性

Specificity/Sensitivity

Caspase-8 (D35G2) Rabbit mAb detects endogenous levels of total caspase-8, including the p10 subunit of the activated protein. Caspase-8 (D35G2) Rabbit mAb may also cross-react with overexpressed levels of caspase-10.

Species Reactivity:

Human, Mouse, Rat

敏感性

Endogenous

背景

Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10 (1-3). Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage. 1.Muzio, M. et al. (1996) Cell 85, 817-27. 2.Boldin, M.P. et al. (1996) Cell 85, 803-15. 3.Fernandes-Alnemri, T. et al. (1996) Proc Natl Acad Sci U S A 93, 7464-9.

研究领域

癌症,细胞生物学,纤维化,神经科学,

翻译后修饰

Unmodified

制备和贮存

保存方式

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

数据库链接

Entrez-Gene ID

841

UniProt ID

Q14790

参考图片

Western blot analysis of extracts from CTLL-2 cells, untreated or treated with cycloheximide (CHX, 10 μg/ml, overnight) followed by Human Tumor Necrosis Factor-α (hTNF-α) #8902 (20 ng/ml, 4 hours), using Caspase-8 (D35G2) Rabbit mAb.

Western blot 检测CTLL-2细胞提取物，未处理 (-)或cycloheximide（放线菌酮）(CHX, 10 μg/ml, 过夜)处理，随后用 Human Tumor Necrosis Factor-α (hTNF-α) #8902 （20 ng/ml, 4 hr）处理，用使用抗体为Caspase-8 (D35G2) Rabbit mAb 兔单抗。

Western blot analysis of extracts from HeLa, THP-1, and YB2/0 cell lines using Caspase-8 (D35G2) Rabbit mAb.

Western blot 检测HeLa，THP-1和YB2/0细胞系提取物，使用抗体为 Caspase-8 (D35G2) Rabbit mAb 兔单抗。

Western blot analysis of 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human Caspase-8 protein (hCasp8-Myc/DDK; +), full-length mouse Caspase-8 protein (mCasp8; +), or full-length human Caspase-10 protein (hCasp10; +), using Caspase-8 (D35G2) Rabbit mAb.

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货号：

4790T

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