Cav2.2/CACNA1B Antibody

Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells. VSCCs are involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. Calcium channel, voltage-dependent, N type, alpha 1B subunit (CACNA1B), or Cav2.2, is encoded by the CACNA1B gene (1,2).  In the brain, Cav2.2 has been implicated in synaptic plasticity (3). Interestingly, altered Cav2.2 may contribute to some neurodegenerative diseases, such as Huntington’s disease (4). 1.Horne, W.A. et al. (1993) Proc Natl Acad Sci U S A 90, 3787-91. 2.Ellinor, P.T. et al. (1993) Nature 363, 455-8. 3.Weiss, J. et al. (2014) Eur J Neurosci 40, 3422-35. 4.Silva, F.R. et al. (2017) Neurobiol Aging 55, 1-10.