InVivoPlus anti-mouse PD-L1 (B7-H1)
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InVivoPlus anti-mouse PD-L1 (B7-H1)

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品牌: BioXcell
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    反应种属:
    mouse
    mouse
    产品介绍
    产品信息
    克隆号
    10F.9G2
    克隆类别
    单抗

    Product Details

    The 10F.9G2™ monoclonal antibody reacts with mouse PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ stimulated monocytes, epithelial cells and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell mediated lysis. In mouse models of melanoma, tumor growth can be transiently arrested via treatment with antibodies which block the interaction between PD-L1 and PD-1. The 10F.9G2™ antibody has been shown to block the interaction between PD-L1 and PD-1 and between PD-L1 and B7-1 (CD80).

    Specifications

    Isotype Rat IgG2b, κ
    Recommended Isotype Control(s)InVivoPlus rat IgG2b isotype control, anti-keyhole limpet hemocyanin
    Recommended Dilution BufferInVivoPure pH 6.5 Dilution Buffer
    Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
    Immunogen Mouse CD274
    Reported Applicationsin vivo PD-L1 blockade
    Immunofluorescence
    Immunohistochemistry (frozen)
    Flow cytometry
    Western blot
    Formulation PBS, pH 6.5
    Contains no stabilizers or preservatives
    Endotoxin* <1EU/mg (<0.001EU/μg)
    Determined by LAL gel clotting assay
    Aggregation* <5%
    Determined by SEC
    Purity >95%
    Determined by SDS-PAGE
    Sterility 0.2 µm filtration
    Production Purified from cell culture supernatant in an animal-free facility
    Purification Protein G
    RRIDAB_10949073
    Molecular Weight 150 kDa
    Murine Pathogen Tests* Ectromelia/Mousepox Virus: Negative
    Hantavirus: Negative
    K Virus: Negative
    Lactate Dehydrogenase-Elevating Virus: Negative
    Lymphocytic Choriomeningitis virus: Negative
    Mouse Adenovirus: Negative
    Mouse Cytomegalovirus: Negative
    Mouse Hepatitis Virus: Negative
    Mouse Minute Virus: Negative
    Mouse Norovirus: Negative
    Mouse Parvovirus: Negative
    Mouse Rotavirus: Negative
    Mycoplasma Pulmonis: Negative
    Pneumonia Virus of Mice: Negative
    Polyoma Virus: Negative
    Reovirus Screen: Negative
    Sendai Virus: Negative
    Theiler’s Murine Encephalomyelitis: Negative
    Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
    * Additional quality control measures for our InVivoPlus™ products include advanced binding validation, murine pathogen screening, protein aggregation screening, and ultra-low endotoxin levels. The superior quality of our InVivoPlus™ products will meet and exceed the strict demands and rigorous standards required for in vivo research. Learn more about the InVivoPlus™ difference here.
    组成成分
    程序性死亡配体蛋白抗体,磷酸盐缓冲液
    应用
    反应种属
    mouse
    背景
    别名
    PD-L1,PDL1,CD274,B7-H1,B7H1,hPD-L1,PD-L1(B7-H1),PDCD1L1,PDCD1LG1,Programmed cell death 1 ligand 1,PDCD1 ligand 1
    研究领域
    Cancer Biology, Immune Checkpoint Protein, Immunology, Tumor Antigens
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    货号:
    BP0101-5MG
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