InVivoPlus anti-mouse CD3ε
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InVivoPlus anti-mouse CD3ε

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品牌: BioXcell
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    反应种属:
    mouse
    mouse
    来源宿主:
    产品介绍
    产品信息
    宿主
    克隆号
    145-2C11
    克隆类别
    单抗

    Product Details

    The 145-2C11 monoclonal antibody reacts with mouse CD3ε, a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. The 145-2C11 antibody has been shown to induce T lymphocyte activation, proliferation, and apoptosis via binding and stimulating the TCR. Additionally, the 145-2C11 antibody has been reported to block the binding of the 17A2 antibody to CD3ε+ T lymphocytes.

    Specifications

    Isotype Armenian Hamster IgG1
    Recommended Isotype Control(s)InVivoPlus polyclonal Armenian hamster IgG
    Recommended Dilution BufferInVivoPure pH 7.0 Dilution Buffer
    Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
    Immunogen Mouse BM10-37 cytotoxic T cells
    Reported Applicationsin vivo T cell depletion
    in vitro T cell stimulation/activation
    Immunofluorescence
    Flow cytometry
    Western blot
    Formulation PBS, pH 7.0
    Contains no stabilizers or preservatives
    Aggregation* <5%
    Determined by SEC
    Purity >95%
    Determined by SDS-PAGE
    Sterility 0.2 µm filtration
    Production Purified from cell culture supernatant in an animal-free facility
    Purification Protein A
    RRIDAB_1107634
    Molecular Weight 150 kDa
    Murine Pathogen Tests* Ectromelia/Mousepox Virus: Negative
    Hantavirus: Negative
    K Virus: Negative
    Lactate Dehydrogenase-Elevating Virus: Negative
    Lymphocytic Choriomeningitis virus: Negative
    Mouse Adenovirus: Negative
    Mouse Cytomegalovirus: Negative
    Mouse Hepatitis Virus: Negative
    Mouse Minute Virus: Negative
    Mouse Norovirus: Negative
    Mouse Parvovirus: Negative
    Mouse Rotavirus: Negative
    Mycoplasma Pulmonis: Negative
    Pneumonia Virus of Mice: Negative
    Polyoma Virus: Negative
    Reovirus Screen: Negative
    Sendai Virus: Negative
    Theiler’s Murine Encephalomyelitis: Negative
    Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
    * Additional quality control measures for our InVivoPlus™ products include advanced binding validation, murine pathogen screening, protein aggregation screening, and ultra-low endotoxin levels. The superior quality of our InVivoPlus™ products will meet and exceed the strict demands and rigorous standards required for in vivo research. Learn more about the InVivoPlus™ difference here.
    组成成分
    跨膜细胞表面蛋白抗体,磷酸盐缓冲液
    应用
    反应种属
    mouse
    背景
    研究领域
    Immunology, Innate Immunity
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    货号:
    BP0001-1-5MG
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