Product Details

The G28.5 monoclonal antibody reacts with human CD40 also known as Bp50. CD40 is a 48 kDa type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD40 is expressed broadly on antigen-presenting cells (APCs) such as dendritic cells, B cells, macrophages, and monocytes as well as non-immune endothelial cells, basal epithelial cells, and a range of tumors. Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. Agonistic CD40 monoclonal antibodies have been shown to activate APCs and promote anti-tumor T cell responses. The G28.5 antibody is an agonistic antibody that has been shown to activate CD40 expressing APCs.

Specifications

Isotype	Mouse IgG1, κ
Recommended Isotype Control(s)	InVivoMAb mouse IgG1 isotype control, unknown specificity
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Conjugation	This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen	Human tonsillar lymphocytes
Reported Applications	in vitro CD40 stimulation Functional assays Flow cytometry
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	<2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
Purity	>95% Determined by SDS-PAGE
Sterility	0.2 µm filtration
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein G
RRID	AB_10950314
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

组成成分

跨膜蛋白抗体，磷酸盐缓冲液

应用

反应种属

human

背景

研究领域

Immune Checkpoint Protein, Immunology, Innate Immunity

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货号：

BE0189-1MG

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