CD69 (H1.2F3) Hamster mAb (PE Conjugate)

CD69, also known as Leu-23, is a type II transmembrane glycoprotein that is expressed on the surface of T cells, B cells, and NK cells (1,2). This phosphorylated disulfide-linked 28 to 32-kDa homodimer is constitutively expressed on a subset of thymocytes and platelets. It also acts as an activation antigen of lymphocytes, NK cells, neutrophils, and eosinophils (1-6). Studies have shown that stimulation of the T cell receptor (TCR) increases the expression of CD69 on the cell surface. The ability to detect the level of CD69 expression after TCR activation makes CD69 an ideal indicator of T cell activation (1). The H1.2F3 antibody is widely used as a marker for T cell activation (7). 1.Testi, R. et al. (1989) J Immunol 142, 1854-60. 2.Marzio, R. et al. (1997) J Leukoc Biol 62, 349-55. 3.Lanier, L.L. et al. (1988) J Exp Med 167, 1572-85. 4.Testi, R. et al. (1988) J Immunol 141, 2557-63. 5.Hartnell, A. et al. (1993) Immunology 80, 281-6. 6.Gavioli, R. et al. (1992) Cell Immunol 142, 186-96. 7.Sobel, E.S. et al. (1993) J Immunol 150, 673-82.