Product Details

The CD69.2.2 monoclonal antibody reacts with mouse CD69, an 85 kDa type II C-type lectin. CD69 expression is rapidly induced upon cell activation in all leukocytes. CD69 is thought to be a negative regulator of the immune response in part through modulating the production of TGF-β. Studies in CD69-deficient mice have revealed that CD69 plays crucial roles in the pathogenesis of various inflammatory diseases including arthritis, asthma, and colitis. When administered in vivo the CD69.2.2 antibody causes CD69 to be internalized but does not deplete CD69+ cells. Anti-CD69-treated mice resemble CD69-/- mice to a remarkable degree. The CD69.2.2 antibody has been shown to activate NK cells in vivo and in vitro and promote anti-tumor responses.

Specifications

Isotype	Mouse IgG1, κ
Recommended Isotype Control(s)	InVivoMAb mouse IgG1 isotype control, unknown specificity
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Conjugation	This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen	CD69+ murine 300-19 pre-B cells
Reported Applications	in vivo down-regulation of CD69 expression Functional assays
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	<2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
Purity	>95% Determined by SDS-PAGE
Sterility	0.2 μM filtered
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein A
RRID	AB_2894750
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

组成成分

C型凝集素蛋白抗体，磷酸盐缓冲液

应用

反应种属

Mouse

背景

研究领域

Cancer Biology, Immunology

声明：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。

货号：

BE0330-1MG

一键复制

询价

1mg

5mg

25mg

50mg

100mg

选择数量

当前规格1件起购

配送至

预计2-3周送达，快递: 免运费，若需干冰额外收费

询价大包装询价