CD8alpha (D4W2Z) XP® Rabbit mAb

CD8alpha (D4W2Z) XP® Rabbit mAb

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品牌: CST
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    分子量:
    35-42
    35-42
    反应种属:
    Mouse
    Mouse
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    产品介绍
    产品信息
    抗原名称
    CD8alpha
    来源纯化
    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp42 of mouse CD8α protein.
    宿主
    Rabbit
    简单描述
    CD8α antibody for detecting a subset of activated peripheral CD4+ T cells. Validated for WB, IHC, IHC. Available in 2 sizes. Click here to learn more.
    商品描述

    Product Usage Information

    ApplicationDilution
    Western Blotting1:1000
    IHC Leica Bond1:200 - 1:800
    Immunohistochemistry (Paraffin)1:200 - 1:800
    分子量
    35-42
    研究领域
    癌症,纤维化,免疫学和肿瘤学,神经科学,
    应用
    反应种属
    Mouse
    目标/特异性

    Specificity/Sensitivity

    CD8α (D4W2Z) XP® Rabbit mAb recognizes endogenous levels of total CD8α protein.

    Species Reactivity:

    Mouse

    敏感性
    Endogenous
    背景
    背景
    Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation (1). 1.Zamoyska, R. (1994) Immunity 1, 243-46.
    研究领域
    癌症,纤维化,免疫学和肿瘤学,神经科学,
    翻译后修饰
    Unmodified
    制备和贮存
    保存方式
    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #60168.
    数据库链接
    Entrez-Gene ID
    12525
    UniProt ID
    P01731

    参考图片

    Western blot analysis of extracts from mouse CD8+ T cells, mouse spleen, EL4 cells, and Raw264.7 cells using CD8α (D4W2Z) XP® Rabbit mAb (Mouse Specific) (upper), and β-Actin (D6A8) Rabbit mAb #8457 (lower).

    Immunohistochemical analysis of paraffin-embedded mouse spleen using CD8α (D4W2Z) XP® Rabbit mAb (Mouse Specific).

    Immunohistochemical analysis of paraffin-embedded mouse small intestine using CD8α (D4W2Z) XP® Rabbit mAb (Mouse Specific).

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    货号:
    98941T
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    20ul
    100ul
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