Product Details

The DECMA-1 monoclonal antibody reacts with the extracellular domain of mouse E-Cadherin, a 120-kDa transmembrane cell-cell adhesion glycoprotein also known as CD324 and uvomorulin. E-Cadherin is widely expressed on epithelial cells in the colon, uterus, liver, keratinocytes, brain, heart, muscle, kidney, and pancreas as well as erythroid cells. E-Cadherin is a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-to-cell adhesion. E-Cadherin is involved in development, bacterial pathogenesis, and tumor invasion. The DECMA-1 antibody has been shown to delay tumor onset and attenuate tumor burden in MMTV-PyMT mice by reducing tumor cell proliferation and inducing apoptosis without any detectable cytotoxicity.

Specifications

Isotype	Rat IgG1, κ
Recommended Isotype Control(s)	InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Conjugation	This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen	Mouse PCC4azal teratocarcinoma cells
Reported Applications	in vivo E-Cadherin neutralization In vitro E-Cadherin neutralization Immunofluorescence Immunoprecipitation Western blot
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	<2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
Purity	>95% Determined by SDS-PAGE
Sterility	0.2 μM filtered
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein G
RRID	AB_2894771
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

组成成分

E钙粘蛋白抗体，磷酸盐缓冲液

应用

反应种属

Mouse

背景

研究领域

Apoptosis, Cancer Biology, Cell Migration & Adhesion, Immunology, Tumor Antigens

声明：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。

货号：

BE0352-1MG

一键复制

询价

1mg

5mg

25mg

50mg

100mg

选择数量

当前规格1件起购

配送至

预计2-3周送达，快递: 免运费，若需干冰额外收费

询价大包装询价