cGAS (C-1)

mouse

抗-cGAS 抗体 C-1 是小鼠单克隆 IgM κ，cGAS抗体, 在1篇文献中引用，规格为200 µg/ml特异性抗原位于human物种的的N-terminus附近的氨基酸23-39之间推荐用于 human 来源的cGAS WB, IP, IF, IHC(P) 和 ELISA检测; not recommended for detection of cGAS of mouse and rat origin; 可能与 an unknown protein of similar size in mouse and rat产生交联反应关于如何获取cGAS (C-1): sc-515802的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。对于cGAS 抗体 (C-1)的WB and IHC(P)应用，m-IgGκ BP-HRP 是首选的二抗检测试剂。现在该试剂和cGAS 抗体 (C-1)组合成套装提供（参见下面的订购信息）。对于其他m-IgGκ BP 偶联产品，参见我们小鼠IgG 结合蛋白的完整列表。 查看产品引用文献(1) cGAS Antibody (C-1) is a high quality monoclonal cGAS antibody (also designated cGAS antibody) suitable for the detection of the cGAS protein of human origin. cGAS Antibody (C-1) is available as the non-conjugated anti-cGAS antibody. The presence of foreign DNA in the cytoplasm induces an antiviral host immune response. DNA in the cytoplasm triggers the production of interferons by activating and synthesis of second messenger cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP). cGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

HumanMB21D1