CGP 42112 (1 mg)

123794

YKHPI

(Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg))

Selective, high affinity AT₂ ligand

1052.2

Selective, high affinity angiotensin AT₂ receptor ligand (K_i = 0.24 nM). Displays agonistic properties at proximal tubule AT₂ receptors, causes Na⁺, K⁺-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC₅₀ = 1850 nM).

≥95% (HPLC)

Soluble to 1 mg/ml in water

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O

C₅₂H₆₉N₁₃O₁₁

127060-75-7