CHIR 99021 (10 mg)

9956119

Highly selective GSK-3 inhibitor; acts as Wnt activator

465.34

6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile

Potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3) (IC₅₀ values are 6.7 and 10 nM for GSK-3β and GSK-3α respectively). Exhibits >500-fold selectivity for GSK-3 over closely related kinases; also displays >800-fold selectivity against 45 additional enzymes and receptors. In combination with tranylcypromine (Cat. No. 3852), enables reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs. Enhances mouse and human ESC self-renewal when used in combination with PD 0325901 (Cat. No. 4192).

≥98% (HPLC)

Soluble to 20 mM in DMSO

CHIR99021,CT99021

ClC(C=C1Cl)=CC=C1C2=NC(NCCNC3=CC=C(C#N)C=N3)=NC=C2C4=NC=C(C)N4

C₂₂H₁₈Cl₂N₈

252917-06-9