Chloropyramine hydrochloride

1/2

Chloropyramine hydrochloride

品牌： Absin

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参数

分子式：

C₁₆H₂₀ClN₃.HCl

分子量：

326.26

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产品介绍

产品信息

抗原名称

FAK-VEGFR-3,H1 receptor

商品描述

Chloropyramine is a first generation antihistamine drug approved in some Eastern European countries for the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions. Related indications for clinical use include Quincke’s edema, allergic reactions to insect bites, food and drug allergies, and anaphylactic shock.

分子量

326.26

纯度

＞98%

可溶性

DMSO : 30 mg/mL (91.95 mM; Need ultrasonic and warming)

外观

白色至类白色结晶性粉末

In vitro(体外研究)

BT474 cells are highly sensitive to Chloropyramine hydrochloride (compound 1) treatment, whereby 1 µM concentrations cause a 40% reduction of viability after 48 h of treatment. It is found that at 1 µM concentrations of Chloropyramine hydrochloride, viability of control MCF7-pcDNA3 cells is significantly higher than the viability of MCF7-VEGFR-3 cells (P.

In vivo(体内研究)

Chloropyramine hydrochloride causes a dramatic reduction of tumor growth in both model systems whereby the tumor size in the treated groups is approximately 20% of the tumor size in vehicle control groups. Doxorubicin administered at 3 mg/kg causes approximately 60% reduction of tumor growth, but has no effect on tumor growth at 0, 3 mg/kg. In contrast, there is a modest effect of Chloropyramine hydrochloride alone (50% reduction of tumor growth). The low-dose combination of Chloropyramine hydrochloride and doxorubicin has a prolonged anti-tumor effect (85% reduction of tumor growth) that is greater than either drug alone.

背景

别名

盐酸氯吡胺

分子式

C₁₆H₂₀ClN₃.HCl

CAS号

6170-42-9

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs816586-25mg

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