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产品介绍
产品信息
商品描述
Cholera toxin （CTB,霍乱毒素B亚基）belongs to the AB5 –subunit family oftoxins.The native hexameric protein has a molecular mass of ~85 kDa and contains two subunits. It consists of a single A subunit (~27.2 kDa), responsible for the ADP-ribosylation activity, and five B subunits(~11.6 kDa each), which are arranged as a pentameric ring with an apparent 5-fold symmetry and are associated with the cell surface receptor binding and subsequent internalization (transmembrane transport)of the enzymatic component.
分子量
11kd
纯度
≥95%
可溶性
H2O: soluble 1mg/mL
外观
powder
来源（爱必信）
E.coli
应用
注意事项
The B subunit is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. The cholera toxin B subunit (CTB) attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. The B subunit has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Recently it has been widely used as a marker of membrane lipid rafts, which are membrane microdomains enriched with cholestrol and sphingolipids. These lipid rafts have an important role in cell signaling and protein trafficking.
背景
别名
霍乱毒素B亚基、CHOLERA TOXIN B SUBUNIT、CTB、 Cholera Toxin B subunit、CTxB、Choleragenoid
技术指标
Format：Recombinant
Sodium azide：Not add.
CAS号
131096-89-4
制备和贮存
保存方式
2–8 °C, The product, as supplied, is stable 2 years when stored properly. Solutions
are stable for at least 3 months when stored at 2–8 °C. DO NOT FREEZE.
参考图片
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危险品化学品经营许可证(不带存储) 许可证编号：沪(杨)应急管危经许[2022]202944(QY) 
营业执照(三证合一)