霍乱毒素B亚单位（FITC conjugated）

品牌： Absin

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参数

分子量：

11kd

CAS号：

131096-89-4

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产品介绍

产品信息

商品描述

Cholera toxin （CTB,霍乱毒素B亚基）belongs to the AB5 –subunit family oftoxins.The native hexameric protein has a molecular mass of ~85 kDa and contains two subunits. It consists of a single A subunit (~27.2 kDa), responsible for the ADP-ribosylation activity, and five B subunits(~11.6 kDa each), which are arranged as a pentameric ring with an apparent 5-fold symmetry and are associated with the cell surface receptor binding and subsequent internalization (transmembrane transport)of the enzymatic component.

分子量

11kd

纯度

≥95%

浓度

See the label for details.

外观

liquid

应用

反应种属

Human;Mouse;Rat;Pig;Zebrafish;Dog;Monkey;Fish

注意事项

The B subunit is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. The cholera toxin B subunit (CTB) attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. The B subunit has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Recently it has been widely used as a marker of membrane lipid rafts, which are membrane microdomains enriched with cholestrol and sphingolipids. These lipid rafts have an important role in cell signaling and protein trafficking.

背景

别名

霍乱毒素B亚基-FITC、CHOLERA TOXIN B SUBUNIT-FITC、CTB-FITC、 Cholera Toxin B subunit-FITC、CTxB-FITC、Choleragenoid-FITC

技术指标

Format：Recombinant Source：E.coli Sodium azide：Not add.

CAS号

131096-89-4

制备和贮存

保存方式

store at -20 ℃ for one year.

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货号：

abs80003-1mg

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1mg

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