CHR 6494 trifluoroac (10 mg)

91691123

Potent and selective haspin inhibitor

406.36

3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate

Potent and selective haspin kinase inhibitor (IC₅₀ = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G₂/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats.

≥98% (HPLC)

Soluble to 100 mM in DMSO

CCCNC2=NN1C(C3=CC(C=NN4)=C4C=C3)=CN=C1C=C2.OC(C(F)(F)F)=O

C₁₆H₁₆N₆.CF₃CO₂H

1458630-17-5