Product Details

The 7H11 monoclonal antibody reacts with mouse CLEC9A (C-type lectin domain family member 9A). CLEC9A, also known as DNGR1 (dendritic cell natural killer lectin group receptor 1) and CD370, is a type II transmembrane glycoprotein with a single extracellular C-type lectin domain. DNGR-1 is restricted in its expression, being found only on CD8α+, CD103+, CD11b− subsets of DCs and plasmacytoid DCs. CLEC9A reportedly functions as an endocytic receptor for necrotic cells. It can mediate the cross-presentation of dead-cell associated antigens by dendritic cells in a Syk-dependent manner. It has been shown that targeting antigen to DNGR-1 on DC’s via coupling antigen to the 7H11 antibody can result in activation of antigen specific CD8+ T cell responses in vivo.

Specifications

Isotype	Rat IgG1, κ
Recommended Isotype Control(s)	InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase
Recommended Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer
Conjugation	This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen	RBL-2H3 cells expressing mouse CLEC9A fused to an HA epitope
Reported Applications	in vivo CLEC9A blockade in vivo Ag targeting to CLEC9A+ DCs Western blot ELISA Immunoprecipitation Immunofluorescence Flow cytometry
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Endotoxin	<2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
Purity	>95% Determined by SDS-PAGE
Sterility	0.2 μM filtered
Production	Purified from cell culture supernatant in an animal-free facility
Purification	Protein G
RRID	AB_2721034
Molecular Weight	150 kDa
Storage	The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.

组成成分

C型凝集素结构域家族9成员A蛋白抗体，磷酸盐缓冲液

应用

反应种属

mouse

背景

研究领域

Cancer Biology, Immunology, Innate Immunity

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货号：

BE0305-1MG

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