Clozapine N-oxide (10 mg)

2819

Activator of hM₃D_q and hM₄D_i DREADDs

342.82

8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Metabolite of clozapine (Cat. No. 0444). Activates human muscarinic designer receptors (DREADDs). Silences hippocampal neurons expressing hM₄ DREADDs in vitro. Suppresses food intake in hyperphagic mice with hM₃Dq-expressing, LMO4-deficient, paraventricular hypothalamic neurons.

≥99% (HPLC)

Soluble to 20 mM in DMSO and to 20 mM in water

CNO

ClC(C=C3)=CC1=C3NC(C=CC=C2)=C2C(N4CC[N+](C)([O-])CC4)=N1

C₁₈H₁₉ClN₄O

34233-69-7