COX1/MT-CO1 (E2I2R) Rabbit mAb

The mitochondrial electron transport chain comprises multiple protein complexes including cytochrome c oxidase. Cytochrome c oxidase catalyzes the reduction of oxygen to water. This process is coupled with pumping protons from the mitochondrial matrix into mitochondrial intermembrane space, contributing to the proton gradient used for ATP synthesis (1). Cytochrome c oxidase consists of 3 mitochondrial DNA-encoded subunits (COX1/MT-CO1, COX2/MT-CO2, and COX3/MT-CO3) and multiple nuclear DNA-encoded subunits (2). Research studies show that the mRNAs of the mitochondrially encoded oxidative phosphorylation subunits, including COX1/MT-CO1, decline significantly during aging (3). 1.Nolfi-Donegan, D. et al. (2020) Redox Biol 37, 101674. 2.Zong, S. et al. (2018) Cell Res 28, 1026-1034. 3.Gomes, A.P. et al. (2013) Cell 155, 1624-38.