CRAMP (140-173) (mouse) (trifluoroacetate salt)

An antimicrobial peptide

Cathelicidin-related antimicrobial peptide (CRAMP) (140-173) is a 34-amino acid peptide derivative of the 38-amino acid antimicrobial peptide CRAMP.1,2 Mature CRAMP is formed from cleavage of the full-length peptide by cathepsin G.3,4 CRAMP (140-173) (1 µg/ml) is active against K. pneumoniae in vitro.1 It decreases neutrophil infiltration of colonic epithelial and luminal surfaces in a porcine model of colitis when administered at a dose of 10 mg/kg.5 Ileal administration of CRAMP (140-173) (10 mg/kg) decreases disease severity and cecal bacterial burden and increases survival in a mouse model of C. difficile infection.6 However, intra-articular administration of CRAMP (140-173) (10 µl of 25 µM) also increases disease severity and induces synovitis in a mouse model of surgery-induced osteoarthritis.7

3878.7

≥95%

Cathelicidin-related Antimicrobial Peptide|Cathelin-related Antimicrobial Peptide|mCRAMP

[H]NCC(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(NCC(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N1CCC[C@H]1C(N[C@@H](CCC(N)=O)C(N2CCC[C@H]2C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O

C178H302N50O46 • XCF3COOH

≥ 4 years

Methanol: Soluble Water: Soluble