Curcumin

1/2

Curcumin

品牌： Absin

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参数

分子式：

C₂₁H₂₀O₆

分子量：

368.38

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产品介绍

产品信息

抗原名称

Nrf2 ,HDAC ,NF-κB ,p300 histone acetylatransferase

商品描述

Curcumin is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM） and Histone deacetylase; activates Nrf2 pathway and supresses the activation of transcription factor NF-κB.

分子量

368.38

纯度

＞98%

可溶性

DMSO : 3.7 mg/mL (10 mM)
Ethanol : 1.8 mg/mL (5 mM)

外观

orange powder

In vitro(体外研究)

Curcumin induces the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. Curcumin inhibits cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1. Curcumin induces endoplasmic reticulum (ER) stress and mitochondrial dysfunction as evidenced by up-regulation of CCAAT/enhancer binding protein homologous protein (CHOP), phosphorylation of JNK and down-regulation of SERCA2ATPase, release of cytochrome c, decrease of Bcl-2 and reduction of mitochondrial membrane potential in both AGS and HT-29 cells.

In vivo(体内研究)

Chronic treatment with curcumin significantly reverses the CMS-induced behavioral abnormalities in stressed rats. Additionally, curcumin effectively inhibits cytokine gene expression at both the mRNA and the protein level and reduces the activation of NF-κB.

背景

别名

姜黄素；

分子式

C₂₁H₂₀O₆

CAS号

458-37-7

制备和贮存

保存方式

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

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货号：

abs815928-50mg

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