Cytokeratin 14 (SPK-14)

mouse

Cytokeratin 14 抗体 DE-SPK14 是小鼠单克隆 IgG1，提供 200 µg/ml 免疫human物种的Cytokeratin 14的氨基酸459-472 推荐用于 mouse, rat, human 和 feline 来源的Cytokeratin 14 WB, IF 和 FCM检测 看 Cytokeratin 14 (LL001): sc-53253，可查看有标记的 Cytokeratin 14 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790 目前，我们还没有完成Cytokeratin 14 抗体 (DE-SPK14)的首选二抗检测试剂的鉴定。这项工作正在进行中。 Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins (also designated KRT14 antibody, or Keratin 14 antibody) play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. In Bowen′s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. The gene encoding human Cytokeratin 14 maps to chromosome 17q12-21. Mutations in this gene lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

IGG-免疫球蛋白G型抗体

MouseKrt14

WB, IF, FCM

3861;16664