Cytokeratin 6 (LL020)

mouse

Cytokeratin 6抗体(LL020)是小鼠单克隆IgM (kappa轻链)，规格为200 µg/ml 免疫human来源Cytokeratin 6的C-terminus 推荐用于 human 来源的Cytokeratin 6 WB, IF 和 IHC(P)检测 看 pan-Cytokeratin (C11): sc-8018，可查看有标记的 Cytokeratin 6 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790 目前，我们还没有完成Cytokeratin 6 抗体 (LL020)的首选二抗检测试剂的鉴定。这项工作正在进行中。 Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins, which are useful markers of tissue differentiation, also aid in the characterization of malignant tumors. IL-1 and TNFα induce transcription of cytokeratin 6 in epidermal keratinocytes via the C/EBP β transcription factor. In humans, multiple isoforms of cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

IGM-免疫球蛋白M型抗体

WB, IF, IHC(P)

3853, 3854, 286887