EGFR Fc Chimera Protein, Rhesus macaque
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EGFR Fc Chimera Protein, Rhesus macaque

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品牌: UA BIOSCIENCE
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    分子量:
    115-125kDa (Reducing)
    115-125kDa (Reducing)
    纯度:

    >95% by SDS-PAGE

    >95% by SDS-PAGE

    产品介绍
    产品信息
    耦联标记
    Unconjugated
    氨基酸序列

    Leu25-Ser645, with C-terminal Human IgG1 Fc

    LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSEFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSSQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCQNVSRGRECVDKCNVLEGEPREFVENSECIQCHPECLPQVMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCARNGPKIPSIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

    分子量
    115-125kDa (Reducing)
    纯度

    >95% by SDS-PAGE

    内毒素水平
    <0.1EU/μg
    性状
    Lyophilized powder
    表达系统
    HEK293
    缓冲体系
    PBS, pH7.4
    标签
    Fc Tag
    种属
    Rhesus macaque
    电泳JSON
    [{"imgUrl":"https://univ-njua.oss-cn-shanghai.aliyuncs.com/prod/202211/f03907a5654f4113b05d0413ca9e5e1d.png","description":"1μg (R: reducing conditions, N: non-reducing conditions)."}]
    背景
    别名
    ERBB,ERRP,HER1,mENA,ERBB1
    背景

    The Epidermal Growth Factor Receptor (EGFR)is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

     EGFR is activated after homodimerization or heterodimerization. Heterodimerization is an important mechanism that allows the activation of all EGFR in response to ligand stimulation. The activated EGFR binds to many signaling proteins and stimulates the activation of many signaling pathways. The specificity and potency of intracellular signaling pathways are determined by positive and negative regulators, the specific composition of activating ligand(s), receptor dimer components, and the diverse range of proteins that associate with the tyrosine phosphorylated C-terminal domain of the EGFR.EGFR is overexpressed or mutated in many cancers, especially in breast cancer, ovarian cancer, and non-small cell lung cancer. The overexpression and overactivation of EGFR is correlated with poor prognosis, drug resistance, cancer metastasis, and lower survival rate.

    制备和贮存
    溶解方法
    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
    保存方式
    • 12 months from date of receipt, -20 to -70 °C as supplied. 
    • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
    • 1 week, 2 to 8 °C under sterile conditions after reconstitution.  
    • Please avoid repeated freeze-thaw cycles.
    数据库链接
    Accession

    参考图片

    1μg (R: reducing conditions, N: non-reducing conditions).

    CM5 Chip captured EGF, Human (Cat. No. UA040003), can bind EGFR Fc Chimera, Rhesus macaque (Cat. No. UA010152) with an affinity constant of 0.32nM as determined in SPR assay.

    Immobilized EGF, Human (Cat. No. UA040003) at 2.0μg/mL (100μL/well) can bind EGFR Fc Chimera, Rhesus macaque (Cat. No. UA010152) with EC50 of 0.22-0.38μg/ml.

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    货号:
    UA010152-100ug
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    询价
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    100μg
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